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August 14, 2020Science ImmunologyOpen Access

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice

Liliane Khoryati Minh N. Pham McKenna Sherve Swarnima Kumari Kevin D. Cook Josh T. Pearson Marika Bogdani Daniel Campbell Marc A. Gavin

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Key Points

The aim is to assess the effectiveness of an IL-2 mutein in promoting regulatory T cell expansion to combat autoimmunity.
Engineered IL-2 mutein was tested in a mouse model of NOD diabetes.
Infrequent dosing schedules were employed to evaluate long-term effects.
The focus was on the selectivity of cell response to IL-2R proximal signaling.
IL-2 mutein treatment led to significant resolution of NOD diabetes in mice.
Effective results observed with reduced dosing frequencies.
Regulatory T cells expanded notably, correlating with disease arrest.

Implication

Shows IL-2 mutein arrests ongoing autoimmunity in mice, indicating therapeutic potential for diabetes.

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Cite This Study

Khoryati et al. (2020) studied this question.

synapsesocial.com/papers/6a5b66b4006b981450d33bfa https://doi.org/10.1126/sciimmunol.aba5264

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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