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April 23, 2026New Journal of Chemistry0 citations

Ginsenoside Rg3-containing ionizable lipid nanoparticles for siRNA delivery

YRYuxin RenHLHanyu LiuJZJingjing Zhao

Key Points

  • To investigate the use of ginsenoside Rg3 in lipid nanoparticles for effective siRNA delivery while addressing safety concerns associated with cholesterol.
  • Utilized ginsenoside Rg3 to formulate ionizable lipid nanoparticles.
  • Evaluated the efficacy of these nanoparticles in delivering siRNA.
  • Assessed the safety profile compared to traditional cholesterol-containing LNPs.
  • Ginsenoside Rg3-enhanced siRNA delivery effectiveness was observed.
  • Reduced adverse effects were indicated when compared to formulations with cholesterol.
  • Demonstrated potential for safer nucleic acid delivery methods.

Abstract

Lipid nanoparticles (LNPs) are promising carriers for nucleic acid delivery. However, Cholesterol (Chol), a common component of LNPs, may cause adverse effects such as allergic reactions and hyperlipidemia upon excessive...

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Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb6fhttps://doi.org/10.1039/d6nj00177g
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