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Ginsenoside Rg3-containing ionizable lipid nanoparticles for siRNA delivery | Synapse

April 23, 2026New Journal of Chemistry0 citations

Ginsenoside Rg3-containing ionizable lipid nanoparticles for siRNA delivery

YRYuxin RenHarbin Institute of Technology HLHanyu LiuHarbin Institute of Technology JZJingjing ZhaoHarbin Institute of Technology

Key Points

To investigate the use of ginsenoside Rg3 in lipid nanoparticles for effective siRNA delivery while addressing safety concerns associated with cholesterol.
Utilized ginsenoside Rg3 to formulate ionizable lipid nanoparticles.
Evaluated the efficacy of these nanoparticles in delivering siRNA.
Assessed the safety profile compared to traditional cholesterol-containing LNPs.
Ginsenoside Rg3-enhanced siRNA delivery effectiveness was observed.
Reduced adverse effects were indicated when compared to formulations with cholesterol.
Demonstrated potential for safer nucleic acid delivery methods.

Abstract

Lipid nanoparticles (LNPs) are promising carriers for nucleic acid delivery. However, Cholesterol (Chol), a common component of LNPs, may cause adverse effects such as allergic reactions and hyperlipidemia upon excessive...

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Cite This Study

Ren et al. (Thu,) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebb6f https://doi.org/https://doi.org/10.1039/d6nj00177g

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