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April 23, 2026Immunity Inflammation and Disease0 citationsOpen Access

ADAMTS2 Modulates Inflammation, Autophagy, and Barrier Integrity Through PI3K/AKT/mTOR Signaling in LPS‐Induced Acute Respiratory Distress Syndrome

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SGSong GaoTLTing LyuYQYouhong Quan

Key Points

  • This research aims to explore the role of ADAMTS2 in modulating inflammation and autophagy during acute respiratory distress syndrome induced by LPS.
  • Knockdown of ADAMTS2 was performed to assess its impact on epithelial injury and barrier integrity.
  • The study evaluated changes in PI3K/AKT/mTOR signaling pathways and autophagy-related responses after LPS treatment.
  • ADAMTS2 knockdown reduced LPS-induced epithelial injury and barrier dysfunction.
  • Changes in PI3K/AKT/mTOR signaling were observed alongside alterations in autophagy.

Abstract

ADAMTS2 knockdown mitigated LPS-induced epithelial injury and barrier dysfunction, in association with PI3K/AKT/mTOR signaling and autophagy-related changes, suggesting ADAMTS2 as a potential therapeutic target for ARDS pending further in vivo validation.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69e9b89b85696592c86ebc1fhttps://doi.org/10.1002/iid3.70429
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