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April 23, 2026Journal of Antimicrobial Chemotherapy0 citations

Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance

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LLLuisa Fernanda Gómez LondoñoASAna Camila Oliveira SouzaBBBrooks Burt

Key Points

  • The study aims to analyze the prevalence of cyp51A variants and their role in triazole antifungal resistance.
  • Analyzed clinical isolates of Aspergillus fumigatus from the US for cyp51A mutations.
  • Conducted a comparative assessment of these mutations' impact on triazole antifungal efficacy.
  • Documented a range of cyp51A mutations contributing to triazole resistance.
  • Highlighted that many cases of resistance remain unexplained by known genetic factors.

Abstract

Our findings demonstrate the range of mutations affecting triazole resistance among US isolates and provide a much-needed side-by-side comparison of the impact of these variants on the most currently used mould-active triazole antifungals. Moreover, they underscore the extent to which triazole resistance remains unexplained by known genetic determinants and the need for further discovery.

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Cite This Study

Londoño et al. (2026) studied this question.

synapsesocial.com/papers/69e9b8d485696592c86ebd1fhttps://doi.org/10.1093/jac/dkag124
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