Menopausal symptoms have marked negative impact on women’s physical and mental well-being and consumes substantial amount of health expenses. However, the relation between H. pylori infection and severity of menopausal symptoms is a scarcely discussed issue. The present cross-sectional study aims to explore the relation between H. pylori infection and severity of menopausal symptoms in diabetic women. The study included 150 postmenopausal diabetic women and 150 non-diabetic counterparts. H. pylori infection was assessed using a monoclonal enzyme immunoassay–based stool antigen test. Menopausal symptoms were evaluated using the Menopause Rating Scale (MRS). The present study included consecutive 150 diabetic and 150 non-diabetic postmenopausal women. Diabetic women had significantly higher frequency of severe menopausal symptoms (31.3% versus 14.0%, p<0.001) and significantly higher frequency of positive H. pylori infection (56.0% versus 40.7%, p = 0.011). Multivariate binary logistic regression analysis identified significant association between BMI OR (95% CI): 1.09 (1.01–1.18), p = 0.022, hypertension OR (95% CI): 3.97 (1.66–9.49), p = 0.002, HbA1c % OR (95% CI): 1.18 (1.02–1.36), p = 0.029 and positive H. pylori infection OR (95% CI): 4.09 (1.52-11.0), p = 0.005 and severe menopausal symptoms. Postmenopausal diabetic women had higher frequency of H. pylori infection which may be related to more severe menopausal symptoms in this population.
Mohamed et al. (Tue,) studied this question.