PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 23, 2026Critical Care Explorations0 citationsOpen Access

Performance of Thromboelastography 6s Difference in Reaction Time Between Heparinase-Free and Heparinase-Containing Channel for Detecting Subtherapeutic Unfractionated Heparin Anticoagulation in a Pediatric Cardiac ICU

View Full Paper
KNKeisuke NishidaYIYusaku ItoKNKota Nakajima

Key Points

  • This research aims to evaluate the effectiveness of thromboelastography ΔR in detecting subtherapeutic heparin levels in a pediatric cardiac ICU setting.
  • Utilized thromboelastography to assess reaction times in heparinase-free and heparinase-containing channels.
  • Compared ΔR values with anti-Xa levels to determine correlation and performance.
  • ΔR showed a moderate correlation with anti-Xa levels, indicating substantial agreement.
  • Demonstrated high discriminative performance in identifying subtherapeutic anticoagulation.

Abstract

ΔR showed a moderate correlation with anti-Xa and high discriminative performance in identifying subtherapeutic anticoagulation, thus supporting its use as a surrogate marker for heparin monitoring in PCICUs. However, further external validation and outcome-based studies are needed to confirm these findings.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Nishida et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb2285696592c86ecf35https://doi.org/10.1097/cce.0000000000001400
Ask AI
Helpful
Bookmark
Share
View Full Paper