What question did this study set out to answer?

This research aims to evaluate the effectiveness of thromboelastography ΔR in detecting subtherapeutic heparin levels in a pediatric cardiac ICU setting.

April 23, 2026Open Access

Performance of Thromboelastography 6s Difference in Reaction Time Between Heparinase-Free and Heparinase-Containing Channel for Detecting Subtherapeutic Unfractionated Heparin Anticoagulation in a Pediatric Cardiac ICU

Key Points

This research aims to evaluate the effectiveness of thromboelastography ΔR in detecting subtherapeutic heparin levels in a pediatric cardiac ICU setting.
Utilized thromboelastography to assess reaction times in heparinase-free and heparinase-containing channels.
Compared ΔR values with anti-Xa levels to determine correlation and performance.
ΔR showed a moderate correlation with anti-Xa levels, indicating substantial agreement.
Demonstrated high discriminative performance in identifying subtherapeutic anticoagulation.

Abstract

ΔR showed a moderate correlation with anti-Xa and high discriminative performance in identifying subtherapeutic anticoagulation, thus supporting its use as a surrogate marker for heparin monitoring in PCICUs. However, further external validation and outcome-based studies are needed to confirm these findings.

Performance of Thromboelastography 6s Difference in Reaction Time Between Heparinase-Free and Heparinase-Containing Channel for Detecting Subtherapeutic Unfractionated Heparin Anticoagulation in a Pediatric Cardiac ICU

Key Points

Abstract

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