High altitude exposure between 2500 m and 8000 m ensures life-sustaining oxygen delivery via increased pulmonary ventilation, cardiac output, and haemoglobin concentration.
Provides clinical recommendations for managing patients with pre-existing cardiovascular conditions during high altitude exposure.
Take home figureAdapted from Bärtsch and Gibbs2 Physiological response to hypoxia. Life-sustaining oxygen delivery, in spite of a reduction in the partial pressure of inhaled oxygen between 25% and 60% (respectively at 2500 m and 8000 m), is ensured by an increase in pulmonary ventilation, an increase in cardiac output by increasing heart rate, changes in vascular tone, as well as an increase in haemoglobin concentration. BP, blood pressure; HR, heart rate; PaCO2, partial pressure of arterial carbon dioxide.
Parati et al. (Fri,) conducted a review in Pre-existing cardiovascular conditions. High altitude exposure was evaluated. High altitude exposure between 2500 m and 8000 m ensures life-sustaining oxygen delivery via increased pulmonary ventilation, cardiac output, and haemoglobin concentration.