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April 24, 2026Japanese Journal of Clinical Oncology0 citations

Prognostic impact of large cribriform architecture and intraductal carcinoma of the prostate in diagnostic biopsies of mCSPC receiving ARPI-based therapy

SSShun SatoJikei University School of Medicine FUFumihiko Urabe YIYu ImaiJikei University School of Medicine

Key Points

Investigate the prognostic significance of large cribriform architecture and intraductal carcinoma in prostate cancer biopsies for mCSPC patients.
Analyzed diagnostic biopsy specimens from mCSPC patients receiving androgen receptor pathway inhibitor-based therapy.
Assessed the presence of large cribriform architecture and intraductal carcinoma of the prostate.
Large-type cribriform architecture correlates with worse outcomes in mCSPC patients.
The prognostic impact of cribriform architecture is similar to that of intraductal carcinoma of the prostate.

Abstract

In diagnostic biopsy specimens, the large-type cribriform architecture is associated with adverse outcomes in mCSPC patients receiving androgen receptor pathway inhibitor-based therapy. Although its prognostic impact overlaps with that of IDC-P, its identification at diagnosis may provide clinically relevant information for contemporary mCSPC management.

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