What question did this study set out to answer?

The study aims to evaluate the relationship between parathyroid hormone (PTH), alkaline phosphatase (ALP), and the risk of fractures in patients with non-dialysis-dependent chronic kidney disease (CKD).

April 25, 2026Osteoporosis International0 citationsOpen Access

Parathyroid hormone and alkaline phosphatase are associated with fracture risk in non-dialysis-dependent chronic kidney disease

CPC. S. H. PichatHerlev Hospital EBE. L. F. BallegaardRigshospitalet IBI. O. BressendorffHerlev Hospital

Key Points

The study aims to evaluate the relationship between parathyroid hormone (PTH), alkaline phosphatase (ALP), and the risk of fractures in patients with non-dialysis-dependent chronic kidney disease (CKD).
Nationwide observational cohort design
Population consisting of individuals with non-dialysis-dependent CKDG3-5
Analysis of fracture risk in relation to levels of PTH and ALP
PTH and ALP levels were positively correlated with increased fracture risk in the CKD cohort.
Specific numerical data are not provided in the abstract, but the association was significant.

Abstract

Our nationwide observational cohort study demonstrates that PTH and ALP were positively associated with fracture risk in non-dialysis-dependent CKDG3-5.

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