Xuebijing alleviates septic myocardial injury by inhibiting iron death mediated by the ICAM1/TLR signaling pathway.

Key Points

• This research aims to investigate how Xuebijing alleviates myocardial injury during sepsis through specific signaling pathways.
• Evaluated the effects of Xuebijing on myocardial injury in sepsis models.
• Examined the role of ICAM1 and TLR signaling pathways in mediating iron death.
• Xuebijing significantly reduced myocardial injury markers compared to control.
• Inhibition of iron death via ICAM1/TLR pathway was observed, enhancing heart function.