Synthesis, characterization, in vitro and in silico studies of novel lophine clubbed acylthioureas

Key Points

• The aim is to design and synthesize a library of novel lophine clubbed acylthioureas.
• Designed a chemical library through multistep synthesis.
• Characterized the resulting compounds for further analysis.
• Successfully synthesized 12 novel lophine clubbed acylthioureas (8a-l).
• Characterization confirmed the structural integrity of the synthesized compounds.