What question did this study set out to answer?

This research aims to explore the relationship between protein lactate modification and diabetic cardiomyopathy (DCM).

April 26, 2026Journal of Diabetes Research0 citationsOpen Access

Integrative Investigation of Lactylome–Proteome Interplay in Diabetic Cardiomyopathy for Pinpointing Disease Development–Associated Pathways or Proteins

DMDi MaHarbin Medical University WCWenjie CaiFujian Medical University HYHui YuanGuangxi University

Key Result

Protein lactate modification and Kla-modified proteins represent promising therapeutic targets for the treatment of diabetic cardiomyopathy.

Key Points

This research aims to explore the relationship between protein lactate modification and diabetic cardiomyopathy (DCM).
Investigated the lactylome and proteome interactions related to DCM.
Identified key proteins modified by lactate for therapeutic targeting.
Presented lactate modification as a promising treatment strategy for DCM.
Established a foundation for identifying Kla and Kla-modified proteins as therapeutic targets.

Structured PICO

Population

Diabetic cardiomyopathy (DCM)

Intervention

Protein lactate modification (Kla and Kla-modified proteins)

Outcome

Disease development-associated pathways or proteinssurrogate

Protein lactate modification (Kla) and Kla-modified proteins may serve as novel therapeutic targets for diabetic cardiomyopathy.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Our findings suggest that protein lactate modification in the lactylome and proteome could be a promising treatment for DCM. This provides a reliable basis for further investigating the roles of Kla and Kla-modified proteins to develop new and effective therapeutic targets for treating DCM.

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