Does L-arginine reverse the hemodynamic and rheological changes caused by acute hyperglycemia in normal subjects?
L-arginine reverses the adverse hemodynamic and rheological effects of acute hyperglycemia, suggesting these effects are mediated by reduced nitric oxide availability.
The results show that acute hyperglycemia in normal subjects causes significant hemodynamic and rheological changes that are reversed by L-arginine. Moreover, the effects of hyperglycemia are mimicked to a large extent, but not entirely, by infusion of L-NMMA. This suggests that hyperglycemia may reduce nitric oxide availability in humans.
Giugliano et al. (1997) studied this question.