Why the study?
Does L-arginine reverse the hemodynamic and rheological changes caused by acute hyperglycemia in normal subjects?
Does L-arginine reverse the hemodynamic and rheological changes caused by acute hyperglycemia in normal subjects?
L-arginine reverses the adverse hemodynamic and rheological effects of acute hyperglycemia, suggesting these effects are mediated by reduced nitric oxide availability.
No immediate clinical implications; leaves open whether L-arginine benefits extend beyond experimental hyperglycemia.
The results show that acute hyperglycemia in normal subjects causes significant hemodynamic and rheological changes that are reversed by L-arginine. Moreover, the effects of hyperglycemia are mimicked to a large extent, but not entirely, by infusion of L-NMMA. This suggests that hyperglycemia may reduce nitric oxide availability in humans.
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Giugliano et al. (1997) studied this question.
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