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July 11, 2000Circulation1,049 citationsOpen Access

Renal Function, Neurohormonal Activation, and Survival in Patients With Chronic Heart Failure

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HHHans L. HillegeAGArmand R. J. GirbesPKPieter Jan de Kam

Key Points

  • To determine the relationship between renal function and mortality compared to cardiac function in chronic heart failure.
  • Assessment of renal function using GFR(c) and cardiac function with LVEF and New York Heart Association class.
  • Evaluation of N-terminal ANP levels in patients with chronic heart failure.
  • Comparison of outcomes based on renal and cardiac function metrics.
  • Impaired renal function (GFR(c)) is a stronger predictor of mortality than impaired cardiac function.
  • Impaired renal function is associated with elevated N-terminal ANP levels.
  • No correlation observed between renal function and LVEF, indicating other causal factors.

Abstract

Impaired renal function (GFR(c)) is a stronger predictor of mortality than impaired cardiac function (LVEF and New York Heart Association class) in advanced CHF, and it is associated with increased levels of N-terminal ANP. Moreover, impaired renal function was not related to LVEF, which suggests that factors other than reduced cardiac output are causally involved.

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Cite This Study

Hillege et al. (2000) studied this question.

synapsesocial.com/papers/69eedf45a84321e0ae63c72chttps://doi.org/10.1161/01.cir.102.2.203
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