What question did this study set out to answer?

This study aimed to understand how silencing SR-B1 influences breast cancer cell behavior and associated molecular pathways.

April 27, 2026Einstein (São Paulo)0 citationsOpen Access

SR-B1 knockdown suppresses breast cancer cell proliferation, migration, and invasion via the PI3K/AKT pathway

MLMing LiJiangsu University YXYanmei XuXian Central Hospital JLJinwen LiNankai University

Key Points

This study aimed to understand how silencing SR-B1 influences breast cancer cell behavior and associated molecular pathways.
Silencing of SR-B1 in breast cancer cells to observe effects on proliferation, migration, and apoptosis.
Assessment of PI3K/AKT pathway activity post SR-B1 knockdown.
Measurement of cyclin D1 and P70 levels following SR-B1 silencing.
SR-B1 knockdown decreases breast cancer cell proliferation and migration significantly.
Increased apoptosis observed after SR-B1 silencing.
Reduced activity of the PI3K/AKT pathway and downregulation of cyclin D1 and P70.

Abstract

Highlights ■ SR-B1 knockdown inhibits breast cancer cell proliferation and migration. ■ Silencing SR-B1 promotes apoptosis in breast cancer cells. ■ PI3K/AKT pathway activity decreases after SR-B1 knockdown. ■ Cyclin D1 and P70 are downregulated following SR-B1 silencing. ABSTRACT Background: The role of scavenger receptor class B type 1 (SR-B1) in breast cancer remains largely unknown. Objective: This study aimed to investigate the effects of SR-B1 on breast cancer cell proliferation, migration, and invasion and to elucidate the underlying mechanisms. ...

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