Provides the first experimental demonstration that localized β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmias.
These data provide the first experimental demonstration that localized β-adrenergic receptor stimulation produces spatiotemporal synchronization of sarcoplasmic reticulum Ca(2+) overload and release in the intact heart and highlight the critical nature of source-sink balance in initiating focal arrhythmias.
Myles et al. (Fri,) studied this question.