Do apical sparing and GLS/EF ratio on echocardiography reliably predict the diagnosis of cardiac amyloidosis in patients undergoing TTE?
GLS/EF ratio may be a more reliable screening tool for cardiac amyloidosis than apical sparing on strain imaging, highlighting a need for improved diagnostic follow-up.
In a broad population of patients undergoing TTE, apical sparing on strain imaging increased the likelihood of CA diagnosis but with modest sensitivity and specificity. GLS/EF ratio may be a more reliable tool to screen for CA. The low rate of complete evaluation in patients with concerning TTE findings indicates a strong need for practice improvement and enhanced disease awareness.
Kyrouac et al. (Wed,) studied this question.