Does higher cardiorespiratory fitness improve metabolic, inflammatory, and oxidative stress biomarkers in adults?
Higher cardiorespiratory fitness is associated with improved metabolic and redox profiles, suggesting a functional CRF threshold could be a practical target to reduce cardiometabolic risk.
correlated with healthier metabolic profiles, less inflammation, and higher antioxidant expression, while inversely correlating with HOMA-IR, MDA, and TNFα. Optimal or high CRF strongly protects against insulin resistance, oxidative stress, inflammation, and metabolic inflexibility, key hallmarks of sedentary behaviour. Regular physical exercise improves metabolic and redox profiles, enhancing antioxidant defences in PBMCs. A functional CRF threshold represents a practical target by which to reduce cardiometabolic risk.
Hernández-López et al. (Sat,) studied this question.
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