The present study aims to report a case of Langerhans cell histiocytosis (LCH) in vulvar topography, a rare condition in clinical practice. This is an observational descriptive study based on the collection of clinical and laboratory data by reviewing the patient’s medical record and of pathological, immunohistochemical, and optical microscopy data related to the case at the Pathological Anatomy Service of HU-UFSC. This report describes histiocytosis of vulvar Langerhans cells in a 19-year-old patient who presented with a single painful nodular vulvar lesion 3 years ago. After multiple treatments for benign conditions, the condition progressed to multiple, nodular lesions associated with pruritus, pain, and discharge of fetid secretion. LCH was diagnosed 2 years after the onset of symptoms by means of histopathological and immunohistochemical analysis. The patient underwent chemotherapy with significant regression of the condition and currently presents with an early recurrence of the lesions. Vulvar LCH is a rare case in gynecology. High diagnostic suspicion of histiocytic syndromes is essential for the correct diagnosis. A multidisciplinary approach to the case is important for the early diagnosis and proper treatment of this entity.
Lopes et al. (Mon,) studied this question.