Genomic and functional approaches point to potential determinants of neonatal K. pneumoniae sepsis

Key Points

• To explore the genomic and functional determinants of neonatal K. pneumoniae sepsis and their impact on clinical outcomes.
• Analyzed positive strains for genomic features and epithelial fitness
• Correlated findings with clinical outcomes in a neonatal cohort
• Positive strains demonstrated enhanced epithelial fitness
• Associated with negative clinical outcomes in the cohort
• Suggested incorporation of genomic markers into neonatal sepsis risk stratification