Aloe-emodin alleviates CUMS-induced depressive-like behavior in male C57BL6 mice via neuroinflammation

Key Points

• This research aims to explore the effects of Aloe-emodin on depressive-like behavior induced by CUMS in mice, focusing on neuroinflammation.
• Utilized CUMS to induce depressive-like behavior in male C57BL6 mice.
• Administered Aloe-emodin to assess its effects on behavior and neuroinflammation.
• Examined microglial activity and immune system responses within the central nervous system.
• Aloe-emodin significantly alleviated depressive-like behaviors in the treated mice.
• Treatment reduced markers of neuroinflammation and microglial activation.
• Findings suggest a correlation between decreased neuroinflammation and improved behavior.