Silent-To-Bright CTCs-Hitchhiking Peptide Nanoprobe for Activatable NIR Imaging of Lung Metastasis in Mice.

Key Points

• This research aims to improve tumor metastasis diagnosis using a novel NIR imaging approach with CTCs.
• Utilized a 'silent-to-bright' NIR imaging technique.
• Leveraged CTCs as carriers for imaging peptides in the metastatic microenvironment.
• Assessed tumor metastasis through fluorescence activation in mouse models.
• Demonstrated effective fluorescence activation in metastatic lesions.
• Achieved significant imaging enhancement with CTCs as carriers.
• Indicated improved diagnostic capability for lung metastasis monitoring.