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May 2, 2026ChemistrySelect

Protective Effects of the Hepatoprotective Phenolic Compounds From Acer Tegmentosum Maxim on Toxoplasma‐Induced Acute Liver Injury in Mice

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Authors

XYXiongjie YinCCChengyu CuiMZMingjing Zhao

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Overview

Randomized trial demonstrates protective effects against Toxoplasma-induced liver injury in mice, suggesting new treatments.

Key Points

  • The aim is to explore the protective effects of phenolic compounds from Acer tegmentosum against Toxoplasma-induced liver injury.
  • Four phenolic compounds were isolated from Acer tegmentosum stem bark and identified via NMR.
  • Liver and spleen indices, serum ALT, AST, GSH, and MDA levels were measured to evaluate hepatoprotective effects.
  • Molecular docking analyzed binding interactions between phenolic compounds and T. gondii calcium-dependent protein kinase 1.
  • Gallic acid showed the strongest anti-T. gondii activity (*p < 0.001).
  • Acer tegmentosum extract significantly reduced serum levels of ALT, AST, and MDA (*p < 0.05).
  • Molecular docking indicated strong binding of compounds to TgCDPK1 with energies between -6.1 to -7.6 kcal/mol.

Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/69f594ca71405d493afffacdhttps://doi.org/10.1002/slct.202506308
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