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This research aims to explore the impact of asymmetric selection on rice immunity and yields through the NLR-TF immune module.

May 3, 20260 citations

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An NLR-TF immune module under asymmetric selection shapes rice immunity and yield.

CHCailin HuHunan Agricultural University YNYuese NingInstitute of Plant Protection WLWei LiHunan Agricultural University

Key Points

This research aims to explore the impact of asymmetric selection on rice immunity and yields through the NLR-TF immune module.
Examined the artificial selection of NLR XA48 and transcription factors OsVOZ1/2 in rice during Xoo infection.
Discussed molecular mechanisms and evolutionary implications of differential selection.
Highlighted potential applications for breeding rice with enhanced resistance.
The NLR-TF immune module (XA48-VOZs) significantly improves rice resistance to Xoo strains.
Asymmetric selection positively influenced grain yield as well as disease resistance.
Combining the NLR-TF module with the PRR XA21 is suggested to enhance broad-spectrum resistance to bacterial leaf blight.

Abstract

Artificial selection of functional genes shapes crops agronomic traits including disease resistance and reproductive development. Recently, Lin et al. (2026) reported that rice nucleotide-binding leucine-rich repeat receptor (NLR) XA48 and its associated transcription factors (TFs) OsVOZ1/2 underwent differential artificial selection upon infection by diverse Xanthomonas oryzae pv. oryzae (Xoo) strains. This asymmetric selection has shaped rice resistance to Xoo and grain yield, uncovering a novel NLR-TF immune module (XA48-VOZs). Here, we discuss the molecular mechanisms of this module, the evolutionary implication of its differential selection, and its potential application, particularly in combination with the pattern-recognition receptor (PRR) XA21 for breeding rice varieties with broad-spectrum resistance to bacterial leaf blight (BLB).

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Cite This Study

Hu et al. (Wed,) studied this question.

synapsesocial.com/papers/69f6e60f8071d4f1bdfc6ab0 https://doi.org/https://doi.org/10.1016/j.molp.2026.04.013

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