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May 3, 20260 citations

Real-World Outcomes of a Complex Outpatient Oral Antimicrobial Therapy COpAT Clinic for Deep-Seated Infections in Singapore.

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TFTiara Joy FooMKMatthew Chung Yi KohJNJinghao Nicholas Ngiam

Key Points

  • This study aims to evaluate the real-world outcomes of an outpatient oral antimicrobial therapy clinic for managing deep-seated infections.
  • Outcomes reported from an observational cohort in Singapore
  • Focus on relapse of infection and oral-to-intravenous antibiotic switch rates
  • Relapse of infection was uncommon
  • Switch from oral to intravenous antibiotics was rare
  • Supports the feasibility of outpatient oral antibiotic therapy for deep-seated infections

Abstract

Following the COPAT randomized trial demonstrating improved safety with early outpatient oral antibiotics, we report outcomes from such a clinic in Singapore. In this observational cohort of deep-seated infections, we found that relapse of infection and oral-to-intravenous antibiotic switch were uncommon, supporting feasibility of this approach in the real-world setting.

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Cite This Study

Foo et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6648071d4f1bdfc7003https://doi.org/10.1016/j.ijid.2026.108750
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