What question did this study set out to answer?

The aim is to develop a rapid assay for quantifying vaccine-induced neutralization antibodies using a hybrid pseudovirion.

May 3, 20261 citations

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Development of a novel hybrid alphavirus-Nipah virus pseudovirion for rapid quantification of vaccine-induced neutralization antibodies.

BHBrian HetrickGeorge Mason University SNSravya Sowdamini NakkaBoston University DYDongyang YuGeorge Mason University

Key Result

The hybrid alphavirus-Nipah virus (Ha-NiV) assay correlated strongly with PRNT (R² = 0.86), demonstrating comparable specificity and sensitivity for quantifying neutralizing antibodies.

Key Points

The aim is to develop a rapid assay for quantifying vaccine-induced neutralization antibodies using a hybrid pseudovirion.
Hybrid alphavirus-Nipah virus pseudovirion was designed for the assay.
Assay was evaluated in BSL-2 settings for its specificity and sensitivity against neutralization antibodies.
Comparison made with traditional PRNT (Plaque Reduction Neutralization Test) techniques.
Ha-NiV assay demonstrated 0.86 correlation with PRNT results, indicating high specificity and sensitivity.
The assay provides a convenient and rapid method for quantifying neutralization antibodies.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

² = 0.86) with PRNT, demonstrating comparable specificity and sensitivity. These results demonstrate that the Ha-NiV assay can serve as a novel platform for convenient and rapid quantification of vaccine-induced nAB in BSL-2 settings.

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Cite This Study

Hetrick et al. (Tue,) reported a other. The hybrid alphavirus-Nipah virus (Ha-NiV) assay correlated strongly with PRNT (R² = 0.86), demonstrating comparable specificity and sensitivity for quantifying neutralizing antibodies.

synapsesocial.com/papers/69f6e6e68071d4f1bdfc7794 https://doi.org/https://doi.org/10.1080/22221751.2026.2660425