Embelia ribes (Vidanga, Jadan) revisited: from traditional Ayurvedic and East Asian use to AI-augmented scaffold-hopping for skin fibrosis with embelin parent and EMB-3 derivative case study

Key Points

• This research aims to investigate the application of Embelia ribes in treating skin fibrosis using advanced techniques.
• Examined traditional uses of Embelia ribes in Ayurvedic and East Asian medicine.
• Utilized AI-augmented scaffold-hopping methods to explore treatment pathways.
• Conducted a case study focusing on embelin and its derivative EMB-3.
• Identified potential for AI-augmented strategies to enhance treatment efficacy for skin fibrosis.
• Demonstrated the relevance of traditional medicinal knowledge in modern therapeutic approaches.