Objectives: Eliminating skin defects using scaffolds, especially hydrogels, has been a promising method to accelerate regeneration. The utilization of hydrogels composed of carboxymethyl chitosan and pullulan oxide, synthesized via Schiff base reaction, represents an effective approach for skin repair. Materials and Methods: , H&E and real-time PCR tests were taken from the removed samples. Experiments confirmed the formation of the Schiff base reaction. Results: ≤0.05). Tissue examination of the samples showed that the rate of angiogenesis and skin repair increased in the hydrogel with the peptide group. The use of peptides strengthened the repair processes in the skin area. Conclusion: These hydrogels represent a promising strategy to promote skin regeneration and provide a significant avenue for future clinical applications in regenerative medicine.
Malekzadeh et al. (Thu,) studied this question.