Abstract Chronic mania is defined as a persistent manic state lasting more than 2 years without remission, often leading to significant functional impairment and resistance to conventional treatments. It poses both diagnostic and management challenges, as prolonged manic symptoms can sometimes be misdiagnosed as schizoaffective disorder, personality disorders, or organic conditions. There have been few reported cases of chronic mania in the literature, highlighting the need for further research on its etiology, treatment strategies, and long-term outcomes. We present here a series of three cases of chronic mania, each with varying clinical course, treatment response, and unique challenges, emphasizing the complexity of managing persistent manic symptoms in different patient profiles.
Ghosh et al. (Mon,) studied this question.