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May 6, 2026Diagnostics0 citationsOpen Access

Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation

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DVD VolkovDSDmytro SkoryiBBBogdan Batsak

Key Points

  • Develop and validate a Python-based method for dynamic intracardiac blood flow evaluation.
  • Developed a program for blood flow visualization using imaging modalities including angiography, MRI, ICE, TEE, TTE.
  • Utilized ECG-gated ICE DICOM images from patients undergoing AF ablation for testing.
  • Produced dynamic flow visualizations and computed the turbulence index and blood mobility fraction.
  • Identified distinct flow patterns in patients with sinus rhythm versus atrial fibrillation.

Abstract

Background/Objectives: To develop and preliminarily evaluate a practical Python-based program for dynamic intracardiac blood flow visualization and the extraction of new quantitative parameters, serving as an initial step toward future flow-based cardiac evaluation. Methods: The method was technically explored across five imaging modalities (angiography, MRI, ICE, TEE, TTE) using standard diagnostic hardware. Preliminary testing used ECG-gated ICE DICOM images from sixteen patients undergoing first-time AF ablation. Results: The program produced dynamic full-chamber flow visualizations and automatically computed two image-derived surrogate markers of flow-pattern behavior, the *turbulence index (TI)* and *blood mobility fraction (BMF)*, across cardiac cycles. Distinct preliminary flow patterns were observed between sinus rhythm and atrial fibrillation. Outputs are exportable for AI analysis. Conclusions: This proof-of-concept approach demonstrates feasibility for routine intracardiac flow assessments, and introduces TI and BMF as potential flow-based biomarkers for future prognostic use after additional validation.

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Cite This Study

Volkov et al. (2026) studied this question.

synapsesocial.com/papers/69fa989404f884e66b5324bfhttps://doi.org/10.3390/diagnostics16091352
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