Abstract Malignant hyperthermia (MH) is a rare pharmacogenetic disorder triggered by inhalational anaesthetics or depolarizing neuromuscular blockers. We report the case of a 13-year-old boy with developmental delay, seizures, and scoliosis who developed a hypermetabolic crisis during scoliosis correction under sevoflurane and succinylcholine. He presented with hypercapnia, tachycardia, hyperthermia, acidosis, hyperkalaemia, and ventricular tachycardia leading to cardiac arrest. Resuscitation achieved return of spontaneous circulation, and stabilization occurred in the pediatric intensive care unit. The MH Clinical Grading Scale score of 88 indicated “almost certain” MH. Dantrolene administration led to rapid recovery. Genetic testing revealed no ryanodine receptor mutation but an EGR2 variant of uncertain significance.
Dave et al. (Sun,) studied this question.