In this Highlights article, allergic asthma and rhinitis are reframed as diseases of epithelial-immune dysregulation. Advances from 2025 establish epithelial-immune circuitry as a central organizing principle of allergic airway inflammation-spanning allergen sensing, memory T-cell function and perpetuation of inflammatory niches-and provide a foundation for next-generation, tissue-directed therapies.
Palmer et al. (Mon,) studied this question.