Facile synthesis of zinc chloride/formic acid based deep eutectic solvents for mild and efficient dissolution of collagen with high concentration

Key Points

• To develop an effective solvent for dissolving collagen that addresses its poor solubility and weak thermostability.
• Synthesis of zinc chloride/formic acid based deep eutectic solvents.
• Investigation of the dissolution capacity of the solvents for collagen.
• Evaluation of the thermostability of the dissolved collagen.
• Deep eutectic solvents showed high efficiency in collagen dissolution.
• Improved solubility of collagen compared to traditional solvents.
• Maintained thermostability of collagen in the presence of the new solvents.