Development of novel chalcone-based quinazoline derivatives as dual VEGFR-2 and EGFR inhibitors

Key Points

• This research aims to develop new compounds that can inhibit both VEGFR-2 and EGFR effectively.
• Developed and synthesized quinazoline-chalcone hybrid compounds (8a-h and 11a-h)
• Verified chemical structures using mass spectrometry
• New hybrid compounds exhibited dual inhibition of VEGFR-2 and EGFR
• Structures of synthesized compounds confirmed through mass spectrometry