A reflection on synthesis by extrusion ten years on: achievements, challenges and opportunities for solvent-free, sustainable, continuous chemical manufacturing

Key Points

• The aim is to reflect on the advancements and challenges in mechanochemical synthesis over the past decade.
• Review of the literature on mechanochemical synthesis and its applications.
• Analysis of the development and implementation of solvent-free techniques in manufacturing.
• Acknowledged significant impact of mechanochemical synthesis in academia and industry.
• Outlined challenges in scaling and adopting efficient solvent-free methods.
• Identified opportunities for innovation in continuous chemical manufacturing.