Locked Nucleic Acid–Nanoparticle Conjugates

Designer nanoparticle conjugates. Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂268/2007/z700262ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.