Vulnerability of GABAergic neurons in SiO2 nanoparticle-exposed 3D human brain organoids and zebrafish larvae models as revealed by techniques with single-cell resolution

Key Points

• This research aims to evaluate the neurotoxic effects of SiO2 nanoparticles on GABAergic neurons.
• Utilized 3D human brain organoids and zebrafish larvae as models.
• Employed techniques with single-cell resolution to assess neuron vulnerability.
• Analyzed the exposure effects of SiO2 nanoparticles on neuronal structures.
• Identified significant vulnerabilities of GABAergic neurons in both models.
• Demonstrated neurotoxic effects associated with SiO2 nanoparticle exposure.
• Highlighted potential underlying mechanisms of toxicity.