This study investigates the continuous-flow hydrolysis reaction of propylene oxide (PO) in a spiral microchannel reactor, integrating experiments, computational fluid dynamics (CFD) simulations, and response surface methodology (RSM). To the best of our knowledge, experimentally determined apparent Arrhenius parameters for PO hydrolysis under microscale continuous-flow conditions remain rarely reported, and afterwards they were incorporated into CFD-based numerical simulations. This combined experimental–numerical framework provides a robust methodology for quantifying and optimizing liquid-phase kinetics in microscale flow environments. Subsequently, CFD simulations were employed to examine key process parameters, including reaction system temperature, inlet flow rate, and reactor length. Finally, RSM was utilized to identify the optimal process conditions (reaction system temperature of 298.15 K, inlet flow rate of 6 × 10−3 m·s−1, and reactor length of 4 m), achieving a predicted PO conversion rate of 81.68%. The study provides a reference for designing and optimizing spiral microchannel reactors for PO hydrolysis.
LI et al. (Tue,) studied this question.