What question did this study set out to answer?

To investigate a unified photoredox platform for SO2-capture transformations and their therapeutic applications.

May 7, 2026Organic Letters0 citations

Unified Photoredox Platform for Divergent SO 2 -Capture Transformations: Substrate-Controlled Switch toward 1,4-HAT-Enabled 1,2-Hydrosulfonylation or 1,2-Sulfonylative Spirolactamization

AVAbhaykumar Vishwakarma RKRahimuddin Khan APAdithya K. P.

Key Points

To investigate a unified photoredox platform for SO2-capture transformations and their therapeutic applications.
Utilized a photoredox strategy for SO2-capture transformations.
Analyzed products for antibacterial and antifungal activity.
Employed mechanistic studies including radical trapping and isotope labeling.
Showed notable antibacterial and antifungal activity of selected products.
Highlighted the therapeutic potential of S(VI) scaffolds in medicinal chemistry.

Abstract

-benzyl analogues selectively furnish sulfonylative spiro-γ-lactams. The method tolerates diverse radical precursors, offers a broad scope, and is supported by mechanistic studies including radical trapping, isotope labeling, and DFT analysis. Selected products show notable antibacterial and antifungal activity, highlighting the therapeutic potential of the resulting S(VI) scaffolds.

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