Systemic thrombolysis with 100 mg recombinant tPA was successfully and safely administered to a patient with massive pulmonary embolism and profound anaemia (haemoglobin 4.5 g/dL).
Case Report (n=1)
No
Thrombolysis can be safely administered for life-threatening massive pulmonary embolism even in the presence of profound anaemia secondary to autoimmune haemolytic anaemia, provided there is no active bleeding.
On arrival, her temperature was 36.5 C, blood pressure 90/50 mmHg, heart rate 108 bpm, respiratory rate 17 breaths/ min, and oxygen saturation 83% (room air).She was pale and icteric but without signs of active bleeding.Cardiopulmonary and abdominal examinations were unremarkable, and rectal examination revealed no blood.
Lau et al. (2026) conducted a case report in Massive pulmonary embolism and profound anaemia (autoimmune haemolytic anaemia) (n=1). Recombinant tPA (rtPA) was evaluated on Clinical recovery and resolution of pulmonary emboli. Systemic thrombolysis with 100 mg recombinant tPA was successfully and safely administered to a patient with massive pulmonary embolism and profound anaemia (haemoglobin 4.5 g/dL).