Basal cell carcinoma (BCC) is the most common malignancy worldwide and is typically associated with favorable outcomes. However, a small subset progresses to locally advanced disease with limited therapeutic options. Here, we report a case of an 83-year-old man who presented with an unresectable scalp lesion treated with vismodegib, who developed liver dysfunction followed by rapid progression to multiple organ failure and death. This case highlights the challenges of managing advanced BCC in elderly patients and the need for careful risk-benefit assessment when considering systemic therapy.
Arenas et al. (Tue,) studied this question.