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This analysis investigates the levels of endothelin-1 and interleukin-6 in ischemic stroke patients treated with different revascularization therapies.

May 8, 2026Open Access

Abstract Number: Esoc2026a1191 Longitudinal Changes in Serum Endothelin-1 and Interleukin-6 Following Acute Ischemic Stroke and Revascularization Therapies

Key Points

This analysis investigates the levels of endothelin-1 and interleukin-6 in ischemic stroke patients treated with different revascularization therapies.
Enrolled 98 imaging-confirmed ischemic stroke patients, aged 18-80, with onset within 24 hours and NIHSS > 1.
Biomarkers were measured at three time points: within 24 hours (T0), at 3-5 days (T1), and at 7±2 days (T2).
Compared endothelin-1 and interleukin-6 levels across revascularization therapies: no procedures, thrombolysis, and endovascular thrombectomy.
Endothelin-1 levels at T0 were higher than controls and were significantly elevated in EVT patients compared to NRP at T0 and T1 (aOR 0.43, 95% CI 0.25-0.74).
Interleukin-6 was also higher in EVT vs. NRP at T0, but not at later time points, indicating a potentially different prognostic role.
Elevated endothelin-1 and interleukin-6 at T0 correlated with poorer outcomes at 90 days, with endothelin-1 particularly associated with lower chances of full recovery.

Abstract

Abstract Background and aims Post-reperfusion complications remain common after ischemic stroke. Biomarkers may clarify mechanisms and identify high-risk patients. We evaluated serum Endothelin-1(Et-1) and Interleukin-6 (IL6), comparing patients by revascularization therapy. Methods We enrolled imaging-confirmed ischemic stroke patients (18-80 years, onset 24h, NIHSS1, pre-stroke mRS2). Those with prior neurological disease, immunosuppression, pregnancy, or severe renal failure were excluded. Twelve healthy controls were considered. Et-1 and IL6 were determined with Ella on samples collected within 24h (T0), 3-5d (T1) and 7±2d (T2). Results Ninety-eight patients were enrolled (59M, median age 68.4yIQR58.6-74.1). At onset, NIHSS was 1-4 in 58.2%, 5-15 in 32.7%, 16 in 9.1%; 44.9% underwent no procedures (NRP), 33.7% thrombolysis (IVT), 11.2% endovascular thrombectomy (EVT), 10.2% IVT+EVT. Et-1 was higher at T0 vs. controls, T1 and T2 (Fig1A); IL6 at T0 vs. controls (Fig. 1B). Between revascularization groups, Et-1 was higher in EVT vs. NRP at T0 and T1 (Fig1C), while IL6 only at T0 (Fig1D). Higher Et-1 and IL6 at T0 were independently associated with lower-odds of good outcome (mRS 0-2) at 90d (Et-1:aOR 0.43, 95%CI 0.25-0.74; IL6:aOR 0.95, 95%CI 0.90-1.00). Only Et-1 was independently associated with lower odds of full recovery to pre-stroke functional status (aOR 0.69, 95%CI 0.51-0.93). Conclusions Et-1 and IL6 peak 24h after stroke, being higher in EVT, with prognostic relevance diverging: IL6 is associated to worse outcome, whereas Et-1 may reflect mechanisms that hinder full neurological recovery. Funding. Ricerca Corrente (IRCCS-Mondino). Conflict of interest Ferrari Federica: nothing to disclose; Loizzo Nicola: nothing to disclose; Mazzacane Federico: nothing to disclose; Del Bello Beatrice: nothing to disclose; Scaranzin Silvia: nothing to disclose; Morandi Chiara: nothing to disclose; Gastaldi Matteo: nothing to disclose; Persico Alessandra: nothing to disclose; Cavallini Anna: nothing to disclose Figure 1 - belongs to Results

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Ferrari et al. (Fri,) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf066ea https://doi.org/https://doi.org/10.1093/esj/aakag023.590

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