From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure

Key Points

• This study aims to establish a framework linking within-host dynamics and population-level epidemic behaviors.
• Developed a multiscale framework bridging immunological dynamics and SIR models.
• Analyzed the influence of within-host measurements on epidemic indicators and control thresholds.
• Identified a relationship between immunological heterogeneity and chronic reservoirs.
• Estimated control thresholds directly from within-host data, enhancing prediction of epidemic dynamics.