Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson’s Disease model | Synapse
Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates autophagy and endoplasmic reticulum stress in rotenone-induced Parkinson’s Disease model
The aim is to evaluate the effects of BRCC3 knockdown using siRNA-loaded niosomes on neuroprotection in a Parkinson’s Disease model.
Utilized siRNA-loaded niosomes for targeted delivery of BRCC3 siRNA.
Investigated effects on autophagy and endoplasmic reticulum stress in a rotenone-induced model of Parkinson’s Disease.
Significant modulation of autophagy pathways observed post-intervention.
Reduction in endoplasmic reticulum stress markers was noted, indicating neuroprotective effects.
Abstract
siRNA-loaded niosomes provides neuroprotection by modulating autophagy, ER stress, and antioxidant pathways, supporting BRCC3 as a promising therapeutic target for PD.