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May 9, 2026ACS Applied Materials & Interfaces0 citations

NaGdF 4 Nanoprobe-Enhanced Multiparametric MRI for Evaluating Diabetes Mellitus-Associated Hepatic Dysfunction and Precancerous Biliary Transformation

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FHFangfei HeYJYanjiao JiangSWShuai Wu

Key Points

  • This research aims to evaluate diabetes-related hepatic dysfunction and biliary transformation using multiparametric MRI enhanced with NaGdF4 nanoprobes.
  • Employs multiparametric MRI to assess hepatic and biliary features.
  • Identifies key imaging markers of liver complications associated with diabetes.
  • Analyzes contrast retention and neovascularization patterns.
  • Identified impaired hepatic metabolic capacity with prolonged contrast retention.
  • Observed progression of biliary tract lesions from intermediate hyperplasia to cholangiocarcinoma.
  • Demonstrated noninvasive insights into liver dysfunction and vascular remodeling.

Abstract

nanoprobes, key imaging features were successfully identified, including impaired hepatic metabolic capacity with prolonged contrast retention, hypoxia-induced neovascularization, and biliary tract lesions progressing from intermediate reactive hyperplasia to advanced cholangiocarcinoma. This multiparameter MRI approach provides noninvasive, high-resolution insights into hepatic metabolic dysfunction, vascular remodeling, and biliary pathology, offering a powerful tool for early diagnosis and prognostic assessment of T2DM-associated liver complications.

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Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/69fecf16b9154b0b82876289https://doi.org/10.1021/acsami.6c04642
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