NaGdF ₄ Nanoprobe-Enhanced Multiparametric MRI for Evaluating Diabetes Mellitus-Associated Hepatic Dysfunction and Precancerous Biliary Transformation

Fangfei He; Yanjiao Jiang; Shuai Wu; Yuqiang Ma; Zhuo Ao; Zhihua Gan; Weiwei Li; Meng Qin; Yi Hou

doi:10.1021/acsami.6c04642

May 6, 2026ACS Applied Materials & Interfaces

NaGdF ₄ Nanoprobe-Enhanced Multiparametric MRI for Evaluating Diabetes Mellitus-Associated Hepatic Dysfunction and Precancerous Biliary Transformation

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Key Points

This research aims to evaluate diabetes-related hepatic dysfunction and biliary transformation using multiparametric MRI enhanced with NaGdF4 nanoprobes.
Employs multiparametric MRI to assess hepatic and biliary features.
Identifies key imaging markers of liver complications associated with diabetes.
Analyzes contrast retention and neovascularization patterns.
Identified impaired hepatic metabolic capacity with prolonged contrast retention.
Observed progression of biliary tract lesions from intermediate hyperplasia to cholangiocarcinoma.
Demonstrated noninvasive insights into liver dysfunction and vascular remodeling.

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Implication

Multiparametric MRI identifies hepatic dysfunction in T2DM, suggesting early diagnostic potential.

Abstract

nanoprobes, key imaging features were successfully identified, including impaired hepatic metabolic capacity with prolonged contrast retention, hypoxia-induced neovascularization, and biliary tract lesions progressing from intermediate reactive hyperplasia to advanced cholangiocarcinoma. This multiparameter MRI approach provides noninvasive, high-resolution insights into hepatic metabolic dysfunction, vascular remodeling, and biliary pathology, offering a powerful tool for early diagnosis and prognostic assessment of T2DM-associated liver complications.

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Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/69fecf16b9154b0b82876289 https://doi.org/10.1021/acsami.6c04642

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NaGdF ₄ Nanoprobe-Enhanced Multiparametric MRI for Evaluating Diabetes Mellitus-Associated Hepatic Dysfunction and Precancerous Biliary Transformation

Key Points

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Implication

Abstract

Discussion

Cite This Study

NaGdF ₄ Nanoprobe-Enhanced Multiparametric MRI for Evaluating Diabetes Mellitus-Associated Hepatic Dysfunction and Precancerous Biliary Transformation

Key Points

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Implication

Abstract

Discussion

Cite This Study

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