A 12-week online supervised exercise program significantly improved peak oxygen uptake (+2.1 ml·kg⁻¹·min⁻¹) compared to usual care in breast cancer survivors after chemotherapy.
RCT (n=167)
Stratified randomization
No
为期12周的有监督在线运动计划是否能改善化疗后乳腺癌幸存者的心肺适能和心率变异性？
为期12周的在线有监督运动计划显著改善化疗后乳腺癌幸存者的心肺适能，但与常规护理相比，未能显著改善心率变异性或生活质量。
Absolute Event Rate: 2.1% vs 0.77%
p-value: p=0.009
Breast cancer survivors are at increased risk of cardiovascular and autonomic dysfunction following adjuvant chemotherapy, and exercise interventions may help mitigate these effects. This randomized prospective study evaluated the effects of a supervised, online-delivered exercise intervention on cardiorespiratory fitness, cardiac autonomic modulation, body composition, and quality of life in breast cancer survivors after chemotherapy. Seventy-two women were allocated to an exercise group or usual care. The intervention consisted of a 12-week home-based exercise program conducted online, with aerobic intensity individualized to 60–80% of peak oxygen uptake. Cardiorespiratory fitness was assessed using cardiopulmonary exercise testing and the 6-min walk test, while heart rate variability was monitored longitudinally and analyzed using linear mixed-effects models. Body composition and patient-reported outcomes were assessed at baseline, post-chemotherapy, and post-intervention. The online supervised exercise resulted in a significant improvement in peak oxygen uptake (+ 2.1 ml kg−1 min−1), which exceeded changes observed in the control group (p = 0.009). Improvements in 6-min walk distance and recovery of heart rate variability occurred irrespective of group allocation. Changes in body composition, quality of life and the improvement of heart rate variability metrics did not differ between groups.
Bohovicová 等（星期四）在乳腺癌患者中进行了一项随机对照试验（n=167）。评估了在线交付的有监督运动程序（SAPA）与常规护理在最高氧气摄取量（VO2peak）变化上的效果（p=0.009）。与常规护理相比，为期12周的在线有监督运动计划显著改善了乳腺癌幸存者在化疗后的最高氧气摄取量（+2.1 ml·kg⁻¹·min⁻¹）。